Aggregation Kinetics for Monoclonal Antibody Products
نویسندگان
چکیده
منابع مشابه
Effective protocol for the investigation of physicochemical and conformational stability and aggregation kinetics measurements of therapeutic IgG2 monoclonal antibody.
Characterisation of monoclonal antibodies (mAbs) represents an ongoing challenge due to their diverse 3-dimensional structures that can affect their stability, immunogenicity and/or toxicity. Although circular dichroism (CD) spectroscopy provides rapid determinations of protein secondary structure in solutions, there is a pressing need for an improvement in current practices in applying the tec...
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The analytical characterization of biopharmaceuticals is a fundamental step in the early stages of development and prediction of their behavior in bioprocesses. Protein aggregation in particular is a common issue as it affects all stages of product development. In the present work, we investigate the stability and the aggregation kinetics of A33Fab, a therapeutically relevant humanized antibody...
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ژورنال
عنوان ژورنال: International Journal of Chemical Engineering and Applications
سال: 2014
ISSN: 2010-0221
DOI: 10.7763/ijcea.2014.v5.424